[⁶⁸Ga]Ga-Schizokinen, a Potential Radiotracer for Selective Bacterial Infection Imaging.

ABSTRACT: Gallium-68-labeled siderophores as radiotracers have gained interest for the development of in situ infection-specific imaging diagnostics. Here, we report radiolabeling, in vitro screening, and in vivo pharmacokinetics (PK) of gallium-68-labeled schizokinen ([⁶⁸Ga]Ga-SKN) as a new potential radiotracer for imaging bacterial infections. We radiolabeled SKN with ≥95% radiochemical purity. Our in vitro studies demonstrated its hydrophilic characteristics, neutral pH stability, and short-term stability in human serum and toward transchelation. In vitro uptake of [⁶⁸Ga]Ga-SKN by Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and S. epidermidis, but no uptake by Candida glabrata, C.

SUBMITTER: Akter A 

PROVIDER: S-EPMC11320569 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature