Liver function maximum capacity test during normothermic regional perfusion predicts graft function after transplantation.

ABSTRACT: In an effort to reduce waitlist mortality, extended criteria donor organs, including those from donation after circulatory death (DCD), are being used with increasing frequency. These donors carry an increased risk for postoperative complications, and balancing donor-recipient risks is currently based on generalized nomograms. Abdominal normothermic regional perfusion (aNRP) enables individual evaluation of DCD organs, but a gold standard to determine suitability for transplantation is lacking. This study aimed to incorporate individualized and predictive measurements of the liver maximum capacity (LiMAx) test to objectively grade liver function during aNRP and prevent post-op complications. aNRP was performed to salvage 18 DCD liver grafts, otherwise discarded. Continuous variables were p

SUBMITTER: Schurink IJ 

PROVIDER: S-EPMC11372035 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature