Regulation of xylose metabolism in recombinant Saccharomyces cerevisiae.

ABSTRACT:

Background

Considerable interest in the bioconversion of lignocellulosic biomass into ethanol has led to metabolic engineering of Saccharomyces cerevisiae for fermentation of xylose. In the present study, the transcriptome and proteome of recombinant, xylose-utilising S. cerevisiae grown in aerobic batch cultures on xylose were compared with those of glucose-grown cells both in glucose repressed and derepressed states. The aim was to study at the genome-wide level how signalling and carbon catabolite repression differ in cells grown on either glucose or xylose. The more detailed knowledge whether xylose is sensed as a fermentable carbon source, capable of catabolite repression like glucose, or is rather recognised as a non-fermentable carbon source is important for further engineer

SUBMITTER: Salusjarvi L 

PROVIDER: S-EPMC2435516 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature