Effect of vitamin K supplementation on insulin resistance in older men and women.

ABSTRACT:

Objective

Vitamin K has a potentially beneficial role in insulin resistance, but evidence is limited in humans. We tested the hypothesis that vitamin K supplementation for 36 months will improve insulin resistance in older men and women.

Research design and methods

This was an ancillary study of a 36-month, randomized, double-blind, controlled trial designed to assess the impact of supplementation with 500 microg/day phylloquinone on bone loss. Study participants were older nondiabetic men and women (n = 355; aged 60-80 years; 60% women). The primary outcome of this study was insulin resistance as measured by homeostasis model assessment (HOMA-IR) at 36 months. Fasting plasma insulin and glucose were examined as the secondary outcomes.

Results

The effect of 36-month v

SUBMITTER: Yoshida M 

PROVIDER: S-EPMC2571052 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature