Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline.

ABSTRACT:

Objective

Our aim was to test the association of vascular risk factor exposure in midlife with progression of MRI markers of brain aging and measures of cognitive decline.

Methods

A total of 1,352 participants without dementia from the prospective Framingham Offspring Cohort Study were examined. Multivariable linear and logistic regressions were implemented to study the association of midlife vascular risk factor exposure with longitudinal change in white matter hyperintensity volume (WMHV), total brain volume (TBV), temporal horn volume, logical memory delayed recall, visual reproductions delayed-recall (VR-d), and Trail-Making Test B-A (TrB-A) performance a decade later.

Results

Hypertension in midlife was associated with accelerated WMHV progression (p < 0.001) and

SUBMITTER: Debette S 

PROVIDER: S-EPMC3146307 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature