Cognitive reserve and midlife vascular risk: Cognitive and clinical outcomes.

ABSTRACT:

Objective

Examine whether cognitive reserve moderates the association of 1) vascular risk factors and 2) white matter hyperintensity burden with risk of clinical progression and longitudinal cognitive decline.

Methods

BIOCARD Study participants were cognitively normal and primarily middle-aged (M = 57 years) at baseline and have been followed with annual cognitive and clinical assessments (M = 13 years). Baseline cognitive reserve was indexed with a composite score combining education with reading and vocabulary scores. Baseline vascular risk (N = 229) was assessed with a composite risk score reflecting five vascular risk factors. Baseline white matter hyperintensity load (N = 271) was measured with FLAIR magnetic resonance imaging. Cox regression models assessed risk of pro

SUBMITTER: Soldan A 

PROVIDER: S-EPMC7448143 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature