Ontology highlight
ABSTRACT:
SUBMITTER: Hellwig S
PROVIDER: S-EPMC3510185 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Hellwig Sabine S Hack Iris I Zucker Birgit B Brunne Bianka B Junghans Dirk D
PloS one 20121129 11
One pathway regulating the migration of neurons during development of the mammalian cortex involves the extracellular matrix protein Reelin. Reelin and components of its signaling cascade, the lipoprotein receptors ApoER2 and Vldlr and the intracellular adapter protein Dab1 are pivotal for a correct layer formation during corticogenesis. The olfactory bulb (OB) as a phylogenetically old cortical region is known to be a prominent site of Reelin expression. Although some aspects of Reelin function ...[more]