Dataset Information
Discovery and activity profiling of thailandepsins A through F, potent histone deacetylase inhibitors, from Burkholderia thailandensis E264.
Ontology highlight
ABSTRACT:
SUBMITTER: Wang C
PROVIDER: S-EPMC3755959 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Publications
Discovery and activity profiling of thailandepsins A through F, potent histone deacetylase inhibitors, from <i>Burkholderia thailandensis</i> E264.
MedChemComm 20120801 8
Three new bicyclic depsipeptides, which are related to the previously reported thailandepsins A (<b>1</b>), B (<b>2</b>) and C (<b>3</b>), were discovered from the culture broth of <i>Burkholderia thailandensis</i> E264 when supplemented with amino acid precursors, and were subsequently named as thailandepsins D (<b>4</b>), E (<b>5</b>) and F (<b>6</b>), respectively. Enzyme assays showed that <b>1-6</b> are potent histone deacetylase (HDAC) inhibitors, particularly toward HDAC1 which represents ...[more]
