Ontology highlight
ABSTRACT:
SUBMITTER: Hu S
PROVIDER: S-EPMC3762332 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
eLife 20130903
DNA methylation, especially CpG methylation at promoter regions, has been generally considered as a potent epigenetic modification that prohibits transcription factor (TF) recruitment, resulting in transcription suppression. Here, we used a protein microarray-based approach to systematically survey the entire human TF family and found numerous purified TFs with methylated CpG (mCpG)-dependent DNA-binding activities. Interestingly, some TFs exhibit specific binding activity to methylated and unme ...[more]