The mycotic ulcer treatment trial: a randomized trial comparing natamycin vs voriconazole.

ABSTRACT:

Objective

To compare topical natamycin vs voriconazole in the treatment of filamentous fungal keratitis.

Methods

This phase 3, double-masked, multicenter trial was designed to randomize 368 patients to voriconazole (1%) or natamycin (5%), applied topically every hour while awake until reepithelialization, then 4 times daily for at least 3 weeks. Eligibility included smear-positive filamentous fungal ulcer and visual acuity of 20/40 to 20/400.

Main outcome measures

The primary outcome was best spectacle-corrected visual acuity at 3 months; secondary outcomes included corneal perforation and/or therapeutic penetrating keratoplasty.

Results

A total of 940 patients were screened and 323 were enrolled. Causative organisms included Fusarium (128 patients [40%]), Aspe

SUBMITTER: Prajna NV 

PROVIDER: S-EPMC3769211 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature