Impaired default network functional connectivity in autosomal dominant Alzheimer disease.

ABSTRACT:

Objective

To investigate default mode network (DMN) functional connectivity MRI (fcMRI) in a large cross-sectional cohort of subjects from families harboring pathogenic presenilin-1 (PSEN1), presenilin-2 (PSEN2), and amyloid precursor protein (APP) mutations participating in the Dominantly Inherited Alzheimer Network.

Methods

Eighty-three mutation carriers and 37 asymptomatic noncarriers from the same families underwent fMRI during resting state at 8 centers in the United States, United Kingdom, and Australia. Using group-independent component analysis, fcMRI was compared using mutation status and Clinical Dementia Rating to stratify groups, and related to each participant's estimated years from expected symptom onset (eYO).

Results

We observed significantly decreased

SUBMITTER: Chhatwal JP 

PROVIDER: S-EPMC3776464 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature