Transcriptional and Proteomic Profiling of Aspergillus flavipes in Response to Sulfur Starvation.

ABSTRACT: Aspergillus flavipes has received considerable interest due to its potential to produce therapeutic enzymes involved in sulfur amino acid metabolism. In natural habitats, A. flavipes survives under sulfur limitations by mobilizing endogenous and exogenous sulfur to operate diverse cellular processes. Sulfur limitation affects virulence and pathogenicity, and modulates proteome of sulfur assimilating enzymes of several fungi. However, there are no previous reports aimed at exploring effects of sulfur limitation on the regulation of A. flavipes sulfur metabolism enzymes at the transcriptional, post-transcriptional and proteomic levels. In this report, we show that sulfur limitation affects morphological and physiological responses of A. flavipes. Transcription and enzymatic activities of sev

SUBMITTER: El-Sayed AS 

PROVIDER: S-EPMC4669086 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature