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ABSTRACT: Introduction
We aimed to investigate if thinner cortex of the Alzheimer's disease (AD)-signature region was related to clinical progression in patients with subjective cognitive decline (SCD).Methods
We included 302 SCD patients with clinical follow-up (≥1 year) and three-dimensional T1 magnetic resonance imaging. We estimated AD-signature cortical thickness, consisting of nine frontal, parietal, and temporal gyri and hippocampal volume. We used Cox proportional hazard models (hazard ratios and 95% confidence intervals) to evaluate cortical thickness in relation to clinical progression to mild cognitive impairment (MCI) or dementia.Results
After a follow-up of the mean (standard deviation) 3 (2) years, 49 patients (16%) showed clinical progression to MCI (n = 32), AD (n = 9), or non-AD dementia (n = 8). Hippocampal volumes, thinner cortex of the AD-signature (hazard ratio [95% confidence interval], 5 [2-17]) and various AD-signature subcomponents were associated with increased risk of clinical progression. Stratified analyses showed that thinner AD-signature cortex was specifically predictive for clinical progression to dementia but not to MCI.Discussion
In SCD patients, thinner regional cortex is associated with clinical progression to dementia.
SUBMITTER: Verfaillie SC
PROVIDER: S-EPMC5198882 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Verfaillie Sander C J SC Tijms Betty B Versteeg Adriaan A Benedictus Marije R MR Bouwman Femke H FH Scheltens Philip P Barkhof Frederik F Vrenken Hugo H van der Flier Wiesje M WM
Alzheimer's & dementia (Amsterdam, Netherlands) 20161119
<h4>Introduction</h4>We aimed to investigate if thinner cortex of the Alzheimer's disease (AD)-signature region was related to clinical progression in patients with subjective cognitive decline (SCD).<h4>Methods</h4>We included 302 SCD patients with clinical follow-up (≥1 year) and three-dimensional T1 magnetic resonance imaging. We estimated AD-signature cortical thickness, consisting of nine frontal, parietal, and temporal gyri and hippocampal volume. We used Cox proportional hazard models (ha ...[more]