History of Bipolar Disorder and the Risk of Dementia: A Systematic Review and Meta-Analysis.
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ABSTRACT: Objective
We carried out a systematic review and meta-analysis to evaluate whether history of bipolar disorder (BD) increases the risk of dementia.Methods
We searched PubMed and Scopus to identify studies that evaluated the risk of dementia in individuals with a history of BD. A total of 6 studies including 3,026 individuals with history of BD and 191,029 non-BD individuals were included in the meta-analysis.Results
History of BD significantly increased the risk of diagnosis of dementia (pooled odds ratio: 2.36; 95% confidence interval: 1.36-4.09; z = 3.07, p < 0.001). Evidence of heterogeneity and of publication bias in the analysis was found.Conclusion
History of BD is associated with significantly higher risk of dementia in older adults. Future studies are necessary to evaluate the potential mediators of this association and to evaluate interventions that may reduce the risk of dementia in this population.
SUBMITTER: Diniz BS
PROVIDER: S-EPMC5365367 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
History of Bipolar Disorder and the Risk of Dementia: A Systematic Review and Meta-Analysis.
Diniz Breno S BS Teixeira Antonio L AL Cao Fei F Gildengers Ariel A Soares Jair C JC Butters Meryl A MA Reynolds Charles F CF
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20170104 4
<h4>Objective</h4>We carried out a systematic review and meta-analysis to evaluate whether history of bipolar disorder (BD) increases the risk of dementia.<h4>Methods</h4>We searched PubMed and Scopus to identify studies that evaluated the risk of dementia in individuals with a history of BD. A total of 6 studies including 3,026 individuals with history of BD and 191,029 non-BD individuals were included in the meta-analysis.<h4>Results</h4>History of BD significantly increased the risk of diagno ...[more]
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