Transcriptional inhibition in Schwann cell development and nerve regeneration.

ABSTRACT: Schwann cells, the myelinating glial cells of the peripheral nervous system are remarkably plastic after nerve trauma. Their transdifferentiation into specialized repair cells after injury shares some features with their development from the neural crest. Both processes are governed by a tightly regulated balance between activators and inhibitors to ensure timely lineage progression and allow re-maturation after nerve injury. Functional recovery after injury is very successful in rodents, however, in humans, lack of regeneration after nerve trauma and loss of function as the result of peripheral neuropathies represents a significant problem. Our understanding of the basic molecular machinery underlying Schwann cell maturation and plasticity has made significant progress in recent years and

SUBMITTER: Quintes S 

PROVIDER: S-EPMC5607813 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature