HIV vaccine candidate activation of hypoxia and the inflammasome in CD14⁺ monocytes is associated with a decreased risk of SIV_mac251 acquisition.

ABSTRACT: Qualitative differences in the innate and adaptive responses elicited by different HIV vaccine candidates have not been thoroughly investigated. We tested the ability of the Aventis Pasteur live recombinant canarypox vector (ALVAC)-SIV, DNA-SIV and Ad26-SIV vaccine prime modalities together with two ALVAC-SIV + gp120 protein boosts to reduce the risk of SIV_mac251 acquisition in rhesus macaques. We found that the DNA and ALVAC prime regimens were effective, but the Ad26 prime was not. The activation of hypoxia and the inflammasome in CD14⁺CD16^- monocytes, gut-homing CCR5-negative CD4⁺ T helper 2 (T_H2) cells and antibodies to variable region 2 correlated with a decreased risk of SIV_mac251 acquisition. By contrast, signal trans

SUBMITTER: Vaccari M 

PROVIDER: S-EPMC5992093 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature