Greater tau load and reduced cortical thickness in APOE ε4-negative Alzheimer's disease: a cohort study.

ABSTRACT:

Background

Alzheimer's disease is characterized by aggregated β-amyloid and tau proteins, but the clinical presentations and patterns of brain atrophy vary substantially. A part of this heterogeneity may be linked to the risk allele APOE ε4. The spread of tau pathology is related to atrophy and cognitive decline, but little data exist on the effects of APOE ε4 on tau. The objective of this preliminary study was therefore to test if tau load and brain structure differ by APOE ε4 in Alzheimer's disease.

Methods

Sixty-five β-amyloid-positive patients at the prodromal and dementia stages of Alzheimer's disease were enrolled, including APOE ε4-positive (n = 46) and APOE ε4-negative (n = 19) patients. ¹⁸F-AV-1451 positron emission tomography was used to measure tau and

SUBMITTER: Mattsson N 

PROVIDER: S-EPMC6081879 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature