Structural Insights into N⁶-methyladenosine (m⁶A) Modification in the Transcriptome.

ABSTRACT: More than 100 types of chemical modifications in RNA have been well documented. Recently, several modifications, such as N⁶-methyladenosine (m⁶A), have been detected in mRNA, opening the window into the realm of epitranscriptomics. The m⁶A modification is the most abundant modification in mRNA and non-coding RNA (ncRNA). At the molecular level, m⁶A affects almost all aspects of mRNA metabolism, including splicing, translation, and stability, as well as microRNA (miRNA) maturation, playing essential roles in a range of cellular processes. The m⁶A modification is regulated by three classes of proteins generally referred to as the "writer" (adenosine methyltransferase), "eraser" (m⁶A demethylating enzyme), and "reader" (m⁶

SUBMITTER: Huang J 

PROVIDER: S-EPMC6112310 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature