Retinal Defocus and Form-Deprivation Exposure Duration Affects RPE BMP Gene Expression.

ABSTRACT: In the context of ocular development and eye growth regulation, retinal defocus and/or image contrast appear key variables although the nature of the signal(s) relayed from the retina to the sclera remains poorly understood. Nonetheless, under optimal visual conditions, eye length is brought into alignment with its optical power to achieve approximate emmetropia, through appropriate adjustment to eye growth. The retinal pigment epithelium (RPE), which lies between the retina and choroid/sclera, appears to play a crucial role in this process. In the investigations reported here, we used a chick model system to assess the threshold duration of exposure to lens-imposed defocus and form-deprivation necessary for conversion of evoked retinal signals into changes in BMP gene expression in the RP

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC6517395 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature