An immune-related gene signature predicts prognosis of gastric cancer.

ABSTRACT:

Background

Although the outcome of patients with gastric cancer (GC) has improved significantly with the recent implementation of annual screening programs. Reliable prognostic biomarkers are still needed due to the disease heterogeneity. Increasing pieces of evidence revealed an association between immune signature and GC prognosis. Thus, we aim to build an immune-related signature that can estimate prognosis for GC.

Methods

For identification of a prognostic immune-related gene signature (IRGS), gene expression profiles and clinical information of patients with GC were collected from 3 public cohorts, divided into training cohort (n = 300) and 2 independent validation cohorts (n = 277 and 433 respectively).

Results

Within 1811 immune genes, a prognostic IRGS consist

SUBMITTER: Jiang B 

PROVIDER: S-EPMC6635287 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature