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Small changes, big implications: The impact of m6A RNA methylation on gene expression in pluripotency and development.

ABSTRACT: In order to maintain a state of self-renewal, yet retain the ability to rapidly differentiate in response to external signals, pluripotent cells exert tight control over gene expression at many levels. Recent studies have suggested that N6-methyladenosine (m6A) RNA methylation, one of the most abundant post-transcriptional modifications, is important for both pluripotency and differentiation. In this review, we summarize the current state of the m6A field, with emphasis on the impact of writers, erasers and readers of m6A on RNA metabolism and stem cell biology.

SUBMITTER: Heck AM

PROVIDER: S-EPMC6742438 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Small changes, big implications: The impact of m6A RNA methylation on gene expression in pluripotency and development.

Heck Adam M AM Wilusz Carol J CJ

Biochimica et biophysica acta. Gene regulatory mechanisms 20190717 9

In order to maintain a state of self-renewal, yet retain the ability to rapidly differentiate in response to external signals, pluripotent cells exert tight control over gene expression at many levels. Recent studies have suggested that N6-methyladenosine (m6A) RNA methylation, one of the most abundant post-transcriptional modifications, is important for both pluripotency and differentiation. In this review, we summarize the current state of the m6A field, with emphasis on ...[more]

PMID: 31325527

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