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[Detection of chitinase 3-like 1 combined with other biomarkers for diagnosis of pancreatic cancer].


ABSTRACT: OBJECTIVE:To assess the value of chitinase 3-like 1 (CHI3L1) alone or in combination with other biomarkers in the diagnosis of pancreatic cancer. METHODS:Serum samples were collected from 70 patients with pancreatic cancer and 31 healthy subjects and the levels of CHI3L1, CA199, C3, C4, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein-cholesterol (LDL-C) in serum were detected. RESULTS:The serum samples from pancreatic cancer patients showed significantly higher CHI3L1, CA199, C3, C4, HDL-C, and LDL-C levels than those from healthy subjects (P<0.05). In patients with pancreatic cancer, serum CHI3L1 level was significantly correlated with the administration of anti-cancer therapy (P<0.05), but not with gender, age, metastasis or other clinicopathological parameters (P<0.05). ROC curve analysis showed that serum CHI3L1, CA199, C3, C4, HDL-C, and LDL-C all had diagnostic value for pancreatic cancer. Multivariate analysis suggested that the combined detection model of CHI3L1, CA199, C3, and HDL-C (AUC=0.964) had a greater diagnostic value than CA199 (AUC=0.896) alone and the combined detection model consisting of CA199, C3, and HDL-C (AUC=0.923; P<0.05). CONCLUSION:Serum levels of CHI3L1, CA199, C3, C4, HDL-C, and LDL-C all have diagnostic value for pancreatic cancer, and the combined model consisting of CHI3L1, CA199, C3, and HDL-C have greater diagnostic efficacy than the other biomarkers either alone or in combination.

SUBMITTER: Ma YF 

PROVIDER: S-EPMC6765668 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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[Detection of chitinase 3-like 1 combined with other biomarkers for diagnosis of pancreatic cancer].

Ma Yan-Fen YF   He Long-Mei LM   Wu Qian Q   Ma Yun-Feng YF   Wang Xiao-Qin XQ  

Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20180401 4


<h4>Objective</h4>To assess the value of chitinase 3-like 1 (CHI3L1) alone or in combination with other biomarkers in the diagnosis of pancreatic cancer.<h4>Methods</h4>Serum samples were collected from 70 patients with pancreatic cancer and 31 healthy subjects and the levels of CHI3L1, CA199, C3, C4, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein-cholesterol (LDL-C) in serum were detected.<h4>Results</h4>The serum samples from pancreatic cancer patients showed signifi  ...[more]

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