Folic acid supplementation and risk of colorectal neoplasia during long-term follow-up of a randomized clinical trial.

ABSTRACT:

Background

The Aspirin/Folate Polyp Prevention Study previously found folic acid increased risk of advanced and multiple colorectal adenomas during a surveillance colonoscopy interval starting about 3 y after randomization.

Objective

We conducted secondary analyses to evaluate folic acid effects with additional follow-up after treatment was stopped.

Methods

In total, 1021 participants recently diagnosed with colorectal adenomas were randomly assigned to 1 mg/d of folic acid (n = 516) or placebo (n = 505), with or without aspirin, beginning 6 July 1994. The original 3-y treatment period was extended into a subsequent colonoscopy interval, but eventually stopped prematurely on 1 October 2004. With additional post-treatment follow-up, a total of 663 participants who exte

SUBMITTER: Passarelli MN 

PROVIDER: S-EPMC6766439 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature