Head-to-head comparison of tau positron emission tomography tracers [¹⁸F]flortaucipir and [¹⁸F]RO948.

ABSTRACT:

Purpose

[¹⁸F]flortaucipir binds to paired helical filament tau and accurately identifies tau in Alzheimer's disease (AD). However, "off-target" binding interferes with the quantification of [¹⁸F]flortaucipir in several brain regions. Recently, other tau PET tracers have been developed. Here, we compare [¹⁸F]flortaucipir with the novel tau tracer [¹⁸F]RO948 head-to-head in vivo.

Methods

We included 18 participants with AD, three with amyloid-β-positive amnestic mild cognitive impairment, and four healthy controls. All underwent [¹⁸F]flortaucipir (80-100 min) and [¹⁸F]RO948 (70-90) PET scans within approximately 1 month. Four study participants underwent 0-100-min dynamic scanning. Standardized uptake value rati

SUBMITTER: Smith R 

PROVIDER: S-EPMC6974501 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature