Dataset Information

¹⁸F-FDG PET/CT total lesion glycolysis is associated with circulating tumor cell counts in patients with stage I to IIIA non-small cell lung cancer.

ABSTRACT:

Background

In non-small cell lung cancer (NSCLC), ¹⁸F-fluoro-2-deoxy-D-glucose (¹⁸F-FDG) uptake determined by PET and presence of circulating tumor cells (CTCs) in the peripheral blood independently predict outcomes. For ¹⁸F-FDG PET/CT staging interpretation, standardized uptake values (SUV_max/avg) are routinely used in clinical reporting. The goal was to investigate whether ¹⁸F-FDG uptake measured by SUV_max/avg, but also measures of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) (MTV × SUV_avg), are associated with CTCs.

Methods

Prospectively, 7.5 mL blood was drawn from NSCLC patients at the time of staging 18F-FDG PET/CT and from healthy control subjects. CTCs were identified by immunofluorescent staining (CK8/18/19^pos/EpCAM^pos/CD45^neg/DAPI^pos nucleus). ¹⁸F-FDG PET/CTs were analyzed for SUV_max, SUV_avg, MTV, and TLG.

Results

In 16 NSCLC patients with stage I-IIIA, MTV and TLG, in contrast to SUV_max and SUV_avg, were positively associated with CTCs (linear regression analysis). No CTCs were detectable in 20 healthy control subjects.

Conclusions

This pilot study demonstrates that ¹⁸F-FDG PET/CT TLG correlates with CTCs in NSCLC patients without distant metastases. TLG might be a more appropriate marker for hematogenous micrometastatic potential than SUVs.

SUBMITTER: Avella DM

PROVIDER: S-EPMC7354116 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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18F-FDG PET/CT total lesion glycolysis is associated with circulating tumor cell counts in patients with stage I to IIIA non-small cell lung cancer.

Avella Diego M DM Manjunath Yariswamy Y Singh Amolak A Deroche Chelsea B CB Kimchi Eric T ET Staveley-O'Carroll Kevin F KF Mitchem Jonathan B JB Kwon Eric E Li Guangfu G Kaifi Jussuf T JT

Translational lung cancer research 20200601 3

<h4>Background</h4>In non-small cell lung cancer (NSCLC), 18F-fluoro-2-deoxy-D-glucose (18F-FDG) uptake determined by PET and presence of circulating tumor cells (CTCs) in the peripheral blood independently predict outcomes. For 18F-FDG PET/CT staging interpretation, standardized uptake values (SUVmax/avg) are routinely used in clinical reporting. The goal was to investigate whether 18F-FDG uptake measured by SUVmax/avg, but also ...[more]

PMID: 32676315

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