Metabolic impact of weight loss induced reduction of adipose ACE-2 - Potential implication in COVID-19 infections?

ABSTRACT:

Background & aims

Angiotensin converting enzyme (ACE)-2 is a modulator of adipose tissue metabolism. However, human data of adipose ACE-2 is rarely available. Considering that, ACE-2 is believed to be the receptor responsible for cell entry of SARS-CoV-2, a better understanding of its regulation is desirable. We therefore characterized the modulation of subcutaneous adipose ACE-2 mRNA expression during weight loss and the impact of ACE-2 expression on weight loss induced short- and long-term improvements of glucose metabolism.

Methods

143 subjects (age > 18; BMI ≥ 27 kg/m²) were analyzed before and after a standardized 12-week dietary weight reduction program. Afterwards subjects were randomized to a 12-month lifestyle intervention or a control group (Maintain-Adu

SUBMITTER: Li L 

PROVIDER: S-EPMC7552972 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature