Association of CXCR6 with COVID-19 severity: Delineating the host genetic factors in transcriptomic regulation.

ABSTRACT:

Background

The coronavirus disease 2019 (COVID-19) is an infectious disease that mainly affects the host respiratory system with ∼80% asymptomatic or mild cases and ∼5% severe cases. Recent genome-wide association studies (GWAS) have identified several genetic loci associated with the severe COVID-19 symptoms. Delineating the genetic variants and genes is important for better understanding its biological mechanisms.

Methods

We implemented integrative approaches, including transcriptome-wide association studies (TWAS), colocalization analysis and functional element prediction analysis, to interpret the genetic risks using two independent GWAS datasets in lung and immune cells. To understand the context-specific molecular alteration, we further performed deep learning-based si

SUBMITTER: Dai Y 

PROVIDER: S-EPMC7899454 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature