Differential gene expression of tumor-infiltrating CD33⁺ myeloid cells in advanced- versus early-stage colorectal cancer.

ABSTRACT: Colorectal cancer (CRC) has high mortality rates, especially in patients with advanced disease stages, who often do not respond to therapy. The cellular components of the tumor microenvironment are essentially responsible for dictating disease progression and response to therapy. Expansion of different myeloid cell subsets in CRC tumors has been reported previously. However, tumor-infiltrating myeloid cells have both pro- and anti-tumor roles in disease progression. In this study, we performed transcriptomic profiling of cells of myeloid lineage (CD33⁺) from bulk CRC tumors at varying disease stages. We identified differentially expressed genes and pathways between CRC patients with advanced stage and early stages. We found that pro-angiogenic and hypoxia-related genes were upre

SUBMITTER: Toor SM 

PROVIDER: S-EPMC7906947 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature