Ontology highlight
ABSTRACT:
SUBMITTER: Son YM
PROVIDER: S-EPMC8056937 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Son Young Min YM Cheon In Su IS Wu Yue Y Li Chaofan C Wang Zheng Z Gao Xiaochen X Chen Yao Y Takahashi Yoshimasa Y Fu Yang-Xin YX Fu Yang-Xin YX Dent Alexander L AL Kaplan Mark H MH Taylor Justin J JJ Cui Weiguo W Sun Jie J
Science immunology 20210101 55
Much remains unknown about the roles of CD4<sup>+</sup> T helper cells in shaping localized memory B cell and CD8<sup>+</sup> T cell immunity in the mucosal tissues. Here, we report that lung T helper cells provide local assistance for the optimal development of tissue-resident memory B and CD8<sup>+</sup> T cells after the resolution of primary influenza virus infection. We have identified a population of T cells in the lung that exhibit characteristics of both follicular T helper and T<sub>RM< ...[more]