Tissue-resident CD4+ T helper cells assist the development of protective respiratory B and CD8+ T cell memory responses.

ABSTRACT: Much remains unknown about the roles of CD4+ T helper cells in shaping localized memory B cell and CD8+ T cell immunity in the mucosal tissues. Here, we report that lung T helper cells provide local assistance for the optimal development of tissue-resident memory B and CD8+ T cells after the resolution of primary influenza virus infection. We have identified a population of T cells in the lung that exhibit characteristics of both follicular T helper and TRM cells, and we have termed these cells as resident helper T (TRH) cells. Optimal TRH cell formation was dependent on transcription factors involved in T follicular helper and resident memory T cell development including BCL6 and Bhlhe40. We show that TRH cells deliver local help to CD8+ T cells through IL-21-dependent mechanisms. Our dat

SUBMITTER: Son YM 

PROVIDER: S-EPMC8056937 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature