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Tissue-resident CD4+ T helper cells assist the development of protective respiratory B and CD8+ T cell memory responses.


ABSTRACT: Much remains unknown about the roles of CD4+ T helper cells in shaping localized memory B cell and CD8+ T cell immunity in the mucosal tissues. Here, we report that lung T helper cells provide local assistance for the optimal development of tissue-resident memory B and CD8+ T cells after the resolution of primary influenza virus infection. We have identified a population of T cells in the lung that exhibit characteristics of both follicular T helper and TRM cells, and we have termed these cells as resident helper T (TRH) cells. Optimal TRH cell formation was dependent on transcription factors involved in T follicular helper and resident memory T cell development including BCL6 and Bhlhe40. We show that TRH cells deliver local help to CD8+ T cells through IL-21-dependent mechanisms. Our data have uncovered the presence of a tissue-resident helper T cell population in the lung that plays a critical role in promoting the development of protective B cell and CD8+ T cell responses.

SUBMITTER: Son YM 

PROVIDER: S-EPMC8056937 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Tissue-resident CD4<sup>+</sup> T helper cells assist the development of protective respiratory B and CD8<sup>+</sup> T cell memory responses.

Son Young Min YM   Cheon In Su IS   Wu Yue Y   Li Chaofan C   Wang Zheng Z   Gao Xiaochen X   Chen Yao Y   Takahashi Yoshimasa Y   Fu Yang-Xin YX   Fu Yang-Xin YX   Dent Alexander L AL   Kaplan Mark H MH   Taylor Justin J JJ   Cui Weiguo W   Sun Jie J  

Science immunology 20210101 55


Much remains unknown about the roles of CD4<sup>+</sup> T helper cells in shaping localized memory B cell and CD8<sup>+</sup> T cell immunity in the mucosal tissues. Here, we report that lung T helper cells provide local assistance for the optimal development of tissue-resident memory B and CD8<sup>+</sup> T cells after the resolution of primary influenza virus infection. We have identified a population of T cells in the lung that exhibit characteristics of both follicular T helper and T<sub>RM<  ...[more]

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