Nicotine metabolite ratio: Comparison of the three urinary versions to the plasma version and nicotine clearance in three clinical studies.

ABSTRACT:

Background

Variation in CYP2A6 activity influences tobacco smoking behaviors and smoking-related health outcomes. Plasma Nicotine Metabolite Ratio (NMR) is a robust phenotypic biomarker of CYP2A6 activity and nicotine clearance. In urine, the NMR has been calculated as a ratio of free trans-3'-hydroxycotinine to free cotinine (NMR_F/F), total trans-3'-hydroxycotinine to free cotinine (NMR_T/F), or total trans-3'-hydroxycotinine to total cotinine (NMR_T/T). We evaluated these three urinary NMR versions relative to plasma NMR and nicotine clearance and elucidated mechanisms of discrepancies among them.

Methods

Baseline plasma and urine biomarker data were available from two smoking cessation clinical trials and one nicotine pharmacokinetic study (

SUBMITTER: Giratallah HK 

PROVIDER: S-EPMC8133391 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature