Effect of race and glucuronidation rates on the relationship between nicotine metabolite ratio and nicotine clearance.

ABSTRACT:

Objectives

To investigate if the nicotine metabolite ratio (NMR, the ratio of nicotine metabolites 3'-hydroxycotinine/cotinine) is a reliable phenotypic biomarker for nicotine clearance across races, and as a function of differences in the rate of nicotine, cotinine and 3'-hydroxycotinine glucuronidation and UGT genotypes.

Methods

Participants [Caucasians (Whites), African Americans (Blacks) and Asian-Americans (Asians)] received an oral solution of deuterium-labeled nicotine and its metabolite cotinine. Plasma and saliva concentrations of nicotine and cotinine were used to determine oral clearances. Rates of glucuronidation were assessed from urine glucuronide/parent ratios, and UGT2B10 and UGT2B17 genotypes from DNA.

Results

Among the 227 participants, 96 (42%) were

SUBMITTER: Liakoni E 

PROVIDER: S-EPMC8184575 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature