Altered gut microbiome compositions are associated with the severity of asthma.

ABSTRACT:

Background

Despite substantial evidence on the contribution of the diversity of the gut microbiome to the pathogenesis of asthma and allergic diseases, little is known about their relationship with asthma severity and/or clinical phenotypes. We analyzed the difference in composition of the gut microbiome between subjects with asthma and healthy subjects and explored its role in the development of asthma.

Methods

Fecal samples from 15 subjects with severe asthma (SA), 14 with non-severe asthma (NSA), and 15 healthy subjects were assessed by 16S ribosomal RNA gene sequencing methods to identify the gut bacterial composition.

Results

Compared with those in the NSA group, patients in the SA group had a higher dose of inhaled corticosteroids, and there were more atopic sub

SUBMITTER: Wang Z 

PROVIDER: S-EPMC8339736 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature