Dataset Information

Altered gut microbiome compositions are associated with the severity of asthma.

ABSTRACT:

Background

Despite substantial evidence on the contribution of the diversity of the gut microbiome to the pathogenesis of asthma and allergic diseases, little is known about their relationship with asthma severity and/or clinical phenotypes. We analyzed the difference in composition of the gut microbiome between subjects with asthma and healthy subjects and explored its role in the development of asthma.

Methods

Fecal samples from 15 subjects with severe asthma (SA), 14 with non-severe asthma (NSA), and 15 healthy subjects were assessed by 16S ribosomal RNA gene sequencing methods to identify the gut bacterial composition.

Results

Compared with those in the NSA group, patients in the SA group had a higher dose of inhaled corticosteroids, and there were more atopic subjects (60% vs. 35.7%, respectively). No significant differences were found at the phylum level either in operational taxonomic unit numbers or in diversity scores among the SA, NSA, and healthy groups. However, at the family level, the relative abundance of Acidaminococcaceae in the SA group was remarkedly lower than that in the group with healthy subjects (P<0.05). Furthermore, Veillonellaceae and Prevotellaceae were significantly more common in samples from the SA group than in those from the NSA group (P<0.05). In the SA group, positive correlations were observed between the relative abundance of Veillonellaceae and mid-expiratory flow 25% (MEF25%) predicted (r=0.538, P=0.047), as well as between the relative abundance of Acidaminococcaceae and body mass index (r=0642, P=0.010). Principal component analysis suggested that the relative abundances of Acidaminococcaceae and Prevotellaceae were associated with severe asthma. Moreover, we found that class Betaproteobacteria, order Burkholderiales, and family Alcaligenaceae were significantly different among the groups defined by serum immunoglobulin E (IgE) levels.

Conclusions

Our findings suggest that altered gut microbiome compositions are involved in the severity of asthma and that there are specific bacteria related to different asthma phenotypes in terms of serum IgE levels.

SUBMITTER: Wang Z

PROVIDER: S-EPMC8339736 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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Publications

Altered gut microbiome compositions are associated with the severity of asthma.

Wang Zhiqiang Z Lai Zhengdao Z Zhang Xiaoxian X Huang Peikai P Xie Jiaxing J Jiang Qian Q Zhang Qingling Q Chung Kian Fan KF

Journal of thoracic disease 20210701 7

<h4>Background</h4>Despite substantial evidence on the contribution of the diversity of the gut microbiome to the pathogenesis of asthma and allergic diseases, little is known about their relationship with asthma severity and/or clinical phenotypes. We analyzed the difference in composition of the gut microbiome between subjects with asthma and healthy subjects and explored its role in the development of asthma.<h4>Methods</h4>Fecal samples from 15 subjects with severe asthma (SA), 14 with non-s ...[more]

PMID: 34422359

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Dataset Information

Altered gut microbiome compositions are associated with the severity of asthma.

Background

Methods

Results

Conclusions

Publications

Altered gut microbiome compositions are associated with the severity of asthma.

Similar Datasets

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