Genetic discovery and risk characterization in type 2 diabetes across diverse populations.

ABSTRACT: Genomic discovery and characterization of risk loci for type 2 diabetes (T2D) have been conducted primarily in individuals of European ancestry. We conducted a multiethnic genome-wide association study of T2D among 53,102 cases and 193,679 control subjects from African, Hispanic, Asian, Native Hawaiian, and European population groups in the Population Architecture Genomics and Epidemiology (PAGE) and Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortia. In individuals of African ancestry, we discovered a risk variant in the TGFB1 gene (rs11466334, risk allele frequency (RAF) = 6.8%, odds ratio [OR] = 1.27, p = 2.06 × 10^-8), which replicated in independent studies of African ancestry (p = 6.26 × 10^-23). We identified a multiethnic risk variant in

SUBMITTER: Polfus LM 

PROVIDER: S-EPMC8486151 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature