Plasma Insulin-like Growth Factor Binding Protein 7 Contributes Causally to ARDS 28-Day Mortality: Evidence From Multistage Mendelian Randomization.

ABSTRACT:

Background

ARDS is a devastating syndrome with heterogeneous subtypes, but few causal biomarkers have been identified.

Research question

Would multistage Mendelian randomization identify new causal protein biomarkers for ARDS 28-day mortality?

Study design and methods

Three hundred moderate to severe ARDS patients were selected randomly from the Molecular Epidemiology of ARDS cohort for proteomics analysis. Orthogonal projections to latent structures discriminant analysis was applied to detect the association between proteins and ARDS 28-day mortality. Candidate proteins were analyzed using generalized summary data-based Mendelian randomization (GSMR). Protein quantitative trait summary statistics were retrieved from the Efficiency and safety of varying the frequency

SUBMITTER: Dong X 

PROVIDER: S-EPMC8501007 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature