Effects of stimulation intensity on intracranial cortico-cortical evoked potentials: A titration study.

ABSTRACT:

Objective

The aim of the present study was to investigate the optimal stimulation parameters for eliciting cortico-cortical evoked potentials (CCEPs) for mapping functional and epileptogenic networks.

Methods

We studied 13 patients with refractory epilepsy undergoing intracranial EEG monitoring. We systematically titrated the intensity of single-pulse electrical stimulation at multiple sites to assess the effect of increasing current on salient features of CCEPs such as N1 potential magnitude, signal to noise ratio, waveform similarity, and spatial distribution of responses. Responses at each incremental stimulation setting were compared to each other and to a final set of responses at the maximum intensity used in each patient (3.5-10 mA, median 6 mA).

Results

We fou

SUBMITTER: Hays MA 

PROVIDER: S-EPMC8545910 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature