Male vitamin D status and male factor infertility.

ABSTRACT:

Objective

To determine the association between vitamin D levels in the male partner and fertility outcomes in couples with mild male factor infertility.

Design

Secondary analysis of a randomized, controlled trial.

Setting

Nine fertility centers in the United States.

Patient(s)

Men (n = 154) with sperm concentration between 5 and 15 million/mL, motility ≤40%, or normal morphology ≤4% were eligible. Female partners were ovulatory, ≤40 years old, and had documented tubal patency.

Intervention(s)

Men provided semen and blood at baseline for semen analysis and 25-hydroxyvitamin D (25(OH)D) levels. They were randomly assigned to receive a vitamin formulation including vitamin D 2,000 IU daily or placebo for up to 6 months. Couples attempted to conceive natural

SUBMITTER: Banks N 

PROVIDER: S-EPMC8561776 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature