Simultaneous radiomethylation of [¹¹C]harmine and [¹¹C]DASB and kinetic modeling approach for serotonergic brain imaging in the same individual.

ABSTRACT: Simultaneous characterization of pathologies by multi-tracer positron emission tomography (PET) is among the most promising applications in nuclear medicine. Aim of this work was the simultaneous production of two PET-tracers in one module and test the relevance for human application. [¹¹C]harmine and [¹¹C]DASB were concurrently synthesized in a 'two-in-one-pot' reaction in quality for application. Dual-tracer protocol was simulated using 16 single PET scans in different orders of tracer application separated by different time intervals. Volume of distribution was calculated for single- and dual-tracer measurements using Logan's plot and arterial input function in 13 brain regions. The 'two-in-one-pot' reaction yielded equivalent amounts of both radiotracers with comp

SUBMITTER: Vraka C 

PROVIDER: S-EPMC8885643 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature