A narrative review on invasive brain stimulation for treatment-resistant depression.

ABSTRACT: While most patients with depression respond to pharmacotherapy and psychotherapy, about one-third will present treatment resistance to these interventions. For patients with treatment-resistant depression (TRD), invasive neurostimulation therapies such as vagus nerve stimulation, deep brain stimulation, and epidural cortical stimulation may be considered. We performed a narrative review of the published literature to identify papers discussing clinical studies with invasive neurostimulation therapies for TRD. After a database search and title and abstract screening, relevant English-language articles were analyzed. Vagus nerve stimulation, approved by the U.S. Food and Drug Administration as a TRD treatment, may take several months to show therapeutic benefits, and the average response rat

SUBMITTER: Dandekar MP 

PROVIDER: S-EPMC9169472 | biostudies-literature | 2022 May-Jun

REPOSITORIES: biostudies-literature