Genetic Obesity Variants and Risk of Conventional Adenomas and Serrated Polyps.

ABSTRACT:

Background

Higher body mass index (BMI) is associated with increased risk of colorectal cancer. How genetically predicted BMI may be associated with colorectal cancer precursors is unknown.

Aims

Our objective was to quantify the association of genetically predicted and measured BMI with risk of colorectal cancer precursors.

Methods

We evaluated the association of genetically predicted and measured BMI with risk of conventional adenomas, serrated polyps, and synchronous polyps among 27,426 participants who had undergone at least one lower gastrointestinal endoscopy in the Nurses' Health Study, Nurses' Health Study II, and Health Professionals Follow-up Study. Genetic risk score was derived from 97 BMI-related single nucleotide polymorphisms. Multivariable logistic regr

SUBMITTER: Bever AM 

PROVIDER: S-EPMC9255950 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature