Smooth muscle cell specific NEMO deficiency inhibits atherosclerosis in ApoE^-/- mice.

ABSTRACT: The development of atherosclerotic plaques is the result of a chronic inflammatory response coordinated by stromal and immune cellular components of the vascular wall. While endothelial cells and leukocytes are well-recognised mediators of inflammation in atherosclerosis, the role of smooth muscle cells (SMCs) remains incompletely understood. Here we aimed to address the role of canonical NF-κB signalling in SMCs in the development of atherosclerosis. We investigated the role of NF-κB signalling in SMCs in atherosclerosis by employing SMC-specific ablation of NEMO, an IKK complex subunit that is essential for canonical NF-κB activation, in ApoE^-/- mice. We show that SMC-specific ablation of NEMO (NEMO^SMCiKO) inhibited high fat diet induced atherosclerosis in ApoE

SUBMITTER: Imai T 

PROVIDER: S-EPMC9307802 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature