Causal associations between changes in lipid profiles and risk of gallstone disease: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Nonalcoholic fatty liver disease (NAFLD) has been linked to gallstone disease (GSD) in observational studies; however, the relationships between certain lipid profiles and GSD remain unclear.

Methods

We adopted a two-sample Mendelian randomization (MR) framework by applying different statistical methods to assess causalities between lipid profiles and GSD. We identified single-nucleotide polymorphisms (SNPs) for blood lipids and NAFLD from separate previous genome-wide association studies (GWASs).

Results

We retrieved GSD SNPs attributed to 10,520 cases and 361,194 controls and validated our estimates using GWAS summary data from UK Biobank. We also performed sex-stratified analyses. Based on the summary estimates of 41, 59, 35, and 2 SNPs for low-density l

SUBMITTER: Yuan X 

PROVIDER: S-EPMC9403919 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature