Lipid peroxidation biomarkers associated with height and obesity measures in the opposite direction in women.

ABSTRACT:

Objective

This study aimed to investigate whether and how lipid peroxidation markers are associated with height and obesity measures.

Methods

In two independent samples of women (Study 1: n = 1,005; Study 2: n = 1,158), systemic levels of lipid peroxidation were assessed by urinary markers F₂ -isoprostanes (F₂ -IsoPs) and its major metabolite (F₂ -IsoP-M), with gas chromatography/negative ion chemical ionization mass spectrometry assays. Anthropometric parameters were directly measured and genetically estimated, and they were used in the primary analysis and in a Mendelian randomization analysis in relation to lipid peroxidation, respectively, with general linear models.

Results

After adjusting for potential confounders, it was found t

SUBMITTER: Li M 

PROVIDER: S-EPMC9556262 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature