Biosynthesis of P(3HB-co-3HHx) Copolymers by a Newly Engineered Strain of Cupriavidus necator PHB^-4/pBBR_CnPro-phaC_Rp for Skin Tissue Engineering Application.

ABSTRACT: Polyhydroxyalkanoates (PHAs) are biodegradable polymers synthesized by certain bacteria and archaea with functions comparable to conventional plastics. Previously, our research group reported a newly PHA-producing bacterial strain, Rhodococcus pyridinivorans BSRT1-1, from the soil in Thailand. However, this strain's PHA synthase (phaC_Rp) gene has not yet been characterized. Thus, this study aims to synthesize PHA using a newly engineered bacterial strain, Cupriavidus necator PHB^-4/pBBR_CnPro-phaC_Rp, which harbors the phaC_Rp from strain BSRT1-1, and characterize the properties of PHA for skin tissue engineering application. To the best of our knowledge, this is the first study on the characterizatio

SUBMITTER: Trakunjae C 

PROVIDER: S-EPMC9570888 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature