Tranexamic Acid Dosing in Craniosynostosis Surgery: A Systematic Review with Meta-analysis

ABSTRACT: Objective: This study aimed to compare operative time, blood loss, and transfusion requirement in patients receiving a high tranexamic acid (TXA) dose of greater than 10 mg/kg versus those receiving a low dose of 10 mg/kg or less.

Methods:

PubMed, Cochrane Central, and Embase were queried to perform a systematic review with meta-analysis. Studies reporting outcomes of TXA use in craniosynostosis surgery were included. TXA dosing, operative time, blood loss, and transfusion requirement were the primary outcomes studied. Other variables studied included age and types of craniosynostosis.

Results:

In total, 398 individuals in the included articles received TXA for craniosynostosis surgery. TXA loading doses ranged from 10 mg/kg to 50 mg/kg. Overall, administration of TXA was

SUBMITTER: O’Donnell D 

PROVIDER: S-EPMC9575957 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature