Association between gut microbiota and preeclampsia-eclampsia: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Several recent observational studies have reported that gut microbiota composition is associated with preeclampsia. However, the causal effect of gut microbiota on preeclampsia-eclampsia is unknown.

Methods

A two-sample Mendelian randomization study was performed using the summary statistics of gut microbiota from the largest available genome-wide association study meta-analysis (n=13,266) conducted by the MiBioGen consortium. The summary statistics of preeclampsia-eclampsia were obtained from the FinnGen consortium R7 release data (5731 cases and 160,670 controls). Inverse variance weighted, maximum likelihood, MR-Egger, weighted median, weighted model, MR-PRESSO, and cML-MA were used to examine the causal association between gut microbiota and preeclampsia-eclam

SUBMITTER: Li P 

PROVIDER: S-EPMC9667679 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature