Survivin promotes a glycolytic switch in CD4⁺ T cells by suppressing the transcription of PFKFB3 in rheumatoid arthritis.

ABSTRACT: In this study, we explore the role of nuclear survivin in maintaining the effector phenotype of IFNγ-producing T cells acting through the transcriptional control of glucose utilization. High expression of survivin in CD4⁺T cells was associated with IFNγ-dependent phenotype and anaerobic glycolysis. Transcriptome of CD4⁺ cells and sequencing of survivin-bound chromatin showed that nuclear survivin had a genome-wide and motif-specific binding to regulatory regions of the genes controlling cell metabolism. Survivin coprecipitates with transcription factors IRF1 and SMAD3, which repressed the transcription of the metabolic check-point enzyme phosphofructokinase 2 gene PFKFB3 and promoted anaerobic glycolysis. Combining transcriptome analyses of CD4⁺ cell

SUBMITTER: Erlandsson MC 

PROVIDER: S-EPMC9678772 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature