RNA N⁶-methyladenosine modification mediates downregulation of NR4A1 to facilitate malignancy of cervical cancer.

ABSTRACT:

Background

N⁶-methyladenosine is the most abundant eukaryotic mRNA modification and alters a wide range of cellular processes in cancer. Therefore, defining the molecular details are critical for understanding the regulatory mechanism of m⁶A modification.

Results

We found that METTL3, a core m⁶A methyltransferase component, is upregulated and functions as an oncogene in cervical cancer. Mechanistically, METTL3 induces the degradation of m⁶A-modified transcripts of NR4A1 though YTHDF2-DDX6 pathway. In addition, NR4A1 overexpression attenuates the malignant progression through recruiting the LSD1/HDAC1/CoREST transcriptional repression complex to AKT1 promoter.

Conclusions

Our findings reveal that m⁶A regulates cerv

SUBMITTER: Yu T 

PROVIDER: S-EPMC9790124 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature