CD4⁺ helper T cells endow cDC1 with cancer-impeding functions in the human tumor micro-environment.

ABSTRACT: Despite their low abundance in the tumor microenvironment (TME), classical type 1 dendritic cells (cDC1) play a pivotal role in anti-cancer immunity, and their abundance positively correlates with patient survival. However, their interaction with CD4⁺ T-cells to potentially enable the cytotoxic T lymphocyte (CTL) response has not been elucidated. Here we show that contact with activated CD4⁺ T-cells enables human ex vivo cDC1, but no other DC types, to induce a CTL response to cell-associated tumor antigens. Single cell transcriptomics reveals that CD4⁺ T-cell help uniquely optimizes cDC1 in many functions that support antigen cross-presentation and T-cell priming, while these changes don't apply to other DC types. We robustly identify "helped" cDC1 in the

SUBMITTER: Lei X 

PROVIDER: S-EPMC9839676 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature