NAMPT is a metabolic checkpoint of IFNγ-producing CD4⁺ T cells in lupus nephritis.

ABSTRACT: Interferon γ (IFNγ) produced by T cells represents the featured cytokine and is central to the pathogenesis of lupus nephritis (LN). Here, we identified nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the salvage NAD⁺ biosynthetic pathway, as playing a key role in controlling IFNγ production by CD4⁺ T cells in LN. Our data revealed that CD4⁺ T cells from LN showed an enhanced NAMPT-mediated NAD⁺ biosynthetic process, which was positively correlated with IFNγ production in CD4⁺ T cells. NAMPT promoted aerobic glycolysis and mitochondrial respiration in CD4⁺ T cells from patients with LN or MRL/lpr mice through the production of NAD⁺. By orchestrating metabolic fitness, NAMPT promoted tra

SUBMITTER: Li M 

PROVIDER: S-EPMC9840150 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature