Effects of hydroxychloroquine on atrial electrophysiology in in silico wild-type and PITX2^+/- atrial cardiomyocytes.

ABSTRACT:

Background

Hydroxychloroquine (HCQ) is commonly used in the treatment of autoimmune diseases and increases the risk of QT interval prolongation. However, it is unclear how HCQ affects atrial electrophysiology and the risk of atrial fibrillation (AF).

Methods

We quantitatively examined the potential atrial arrhythmogenic effects of HCQ on AF using a computational model of human atrial cardiomyocytes. We measured atrial electrophysiological markers after systematically varying HCQ concentrations.

Results

The HCQ concentrations were positively correlated with the action potential duration (APD), resting membrane potential, refractory period, APD alternans threshold, and calcium transient alternans threshold (p < 0.05). By contrast, HCQ concentrations were inversely corre

SUBMITTER: Song E 

PROVIDER: S-EPMC9894744 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature